Thermo Fisher Scientific PD-L2 (PDCD1LG2) Monoclonal Antibody (OTI10G2), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

Programmed death-ligand 2 (PD-L2), also known as B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it serves as a ligand for programmed cell death protein 1 (PD-1). PD-L2 is primarily expressed in dendritic cells but can be induced in various immune and non-immune cells depending on the microenvironment. Its expression is upregulated by cytokines such as IL-4, TNF-alpha, and IFN-gamma.

PD-L2 has a 2–6 times higher relative affinity to PD-1 than PD-L1. PD-1 and its ligands act as inhibitory immune checkpoint molecules, providing negative feedback for immune homeostasis. Binding of PD-L2 or PD-L1 to PD-1 inhibits T-cell activation, proliferation, and cytokine secretion (e.g., IFN-gamma, IL-10), thereby modulating immune response.

Recent studies indicate PD-L2 also interacts with a second receptor, repulsive guidance molecule b (RGMb), which is involved in BMP and neogenin signaling pathways and contributes to respiratory tolerance development in the lung.

The naturally occurring human PD-L2 monomer consists of:

• 201 amino acids (extracellular domain)
• 21 amino acids (transmembrane domain)
• 32 amino acids (cytoplasmic domain)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.