Thermo Fisher Scientific SOS1 Polyclonal Antibody
SOS1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 및 Rat 시료에 반응합니다. Western blot, IHC (Paraffin), ICC/IF에 사용 가능하며, Protein G로 정제된 액상 형태입니다. 연구용으로 Ras 신호전달 관련 연구에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Son of sevenless homolog 1 protein (1140–1281aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.885 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2902300 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1 and its closely related Sos2 paralog consist of several domains: an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region. Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras, activating the MAPK cascade central to cellular proliferation, survival, and differentiation. Growth factor stimulation rapidly induces phosphorylation of Sos on multiple serine and threonine residues, disrupting the Grb2-Sos complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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