Thermo Fisher Scientific CD153 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human CD153 (TNFSF8). Validated for IHC (paraffin) with 1:25–1:100 dilution. Supplied in PBS with 40% glycerol, 0.05% sodium azide. For research use only.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:25–1:100 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the N-terminal of human TNFSF8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2688410 |
Target Information
The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects such as cell proliferation, activation, differentiation, and apoptotic cell death. CD30 plays a critical role in the pathophysiology of Hodgkin’s disease and other CD30⁺ lymphomas. It also acts as a costimulatory molecule in thymic negative selection. CD30 expression is found on Hodgkin’s and Reed-Sternberg cells, some non-Hodgkin’s lymphomas (including Burkitt’s lymphomas), virus-infected T and B cells, and activated normal T and B cells. In T cells, CD30 is expressed on subsets producing Th2-type cytokines and on CD4⁺/CD8⁺ thymocytes coexpressing CD45RO and the IL-4 receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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