Thermo Fisher Scientific MKNK2 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB)

Tested Dilution

• 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MVQKKPAELQ GFHRSFKGQN PFELAFSLDQ PDHGDSDFGL QCSARPDMPA SQPIDIPDAK KRGKKKKRGR ATDSFSGRFE DVYQLQEDVL GEGAHARVQT CINLITSQEY AVKIIEKQPG HIRSRVFREV EMLYQCQGHR NVLELIEFFE EEDRFYLVFE KMRGGSILSH IHKRRHFNEL EASVVVQDVA SALDFLHNKG IAHRDLKPEN ILCEHPNQVS PVKICDFDLG SGIKLNGDCS PISTPELLTP CGSAEYMAPE VVEAFSEEAS IYDKRCDLWS LGVILYILLS GYPPFVGRCG SDCGWDRGEA CPACQNMLFE SIQEGKYEFP DKDWAHISCA AKDLISKLLV RDAKQRLSAA QVLQHPWVQG CAPENTLPTP MVLQRWDSHF LLPPHPCRIH VRPGGLVRTV TVNE

Target Information

The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases and regulate protein synthesis by phosphorylating eIF4E on Ser209, potentially contributing to tumorigenesis. Overexpression of Mnk2 increases phosphorylation of endogenous eIF-4E, indicating its role as an eIF-4E kinase in vivo. Mnk2 may also participate in cellular responses to environmental stress and cytokines. Active mutants of MNK1 and MNK2 reduce cap-dependent translation in 293 cells. Human Mnk2 shows ~94% identity with murine Mnk2 and 71% with human Mnk1. In vitro studies indicate Mnk2 is a better substrate than Mnk1 for Erk2, p38MAPKα, and p38MAPKβ.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.