Thermo Fisher Scientific PIK3C2A Monoclonal Antibody (OTI3G9), TrueMAB
Human PIK3C2A 단백질을 인식하는 mouse monoclonal antibody로, Western blot에 최적화되어 있습니다. Lyophilized 형태이며, carrier-free로 conjugation 실험에 적합합니다. Affinity chromatography로 정제되어 높은 순도와 재현성을 제공합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G9 |
| Immunogen | Human recombinant protein fragment (aa 230–560 of PIK3C2A, produced in E. coli) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve ~1 mg/mL final concentration.
- For conjugation experiments, perform additional desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. These enzymes are involved in receptor-mediated cellular processes such as insulin signaling, neuronal survival, and growth factor signaling.
PI3 kinases play critical roles in cell proliferation, oncogenic transformation, survival, migration, and intracellular trafficking.
PIK3C2A contains a lipid kinase catalytic domain and a C-terminal C2 domain, which mediates calcium-dependent phospholipid binding and protein-protein interactions.
Its activity is not sensitive to nanomolar levels of wortmannin and may be activated by insulin, suggesting involvement in integrin-dependent signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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