Thermo Fisher Scientific PIK3C2A Monoclonal Antibody (OTI3G9), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to achieve ~1 mg/mL final concentration.
• For conjugation experiments, perform additional desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. These enzymes are involved in receptor-mediated cellular processes such as insulin signaling, neuronal survival, and growth factor signaling.
PI3 kinases play critical roles in cell proliferation, oncogenic transformation, survival, migration, and intracellular trafficking.
PIK3C2A contains a lipid kinase catalytic domain and a C-terminal C2 domain, which mediates calcium-dependent phospholipid binding and protein-protein interactions.
Its activity is not sensitive to nanomolar levels of wortmannin and may be activated by insulin, suggesting involvement in integrin-dependent signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.