Thermo Fisher Scientific KCTD13 Monoclonal Antibody (OTI7D5), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Target Information

Cytochrome P450 super family proteins are monooxygenases catalyzing various biochemical reactions related to drug metabolism and synthesis of cholesterol, steroids, and lipids.
CYP4F3, a 60 kDa protein, is a novel member of this family with a conserved heme-binding domain near the C-terminus and catalyzes the ω-hydroxylation of LTB4.
It is localized in the ER and plays a crucial role in inactivating LTB4 and controlling inflammation.
CYP4F3 exists in two isoforms:

• CYP4F3A: Neutrophil isoform expressed in neutrophils and myeloid cells; catalyzes microsomal ω-hydroxylation of LTB4 and regulates bone marrow cell development.
• CYP4F3B: Liver isoform; catalyzes conversion of arachidonic acid to 20-HETE, a potent PKC activator involved in cell proliferation, vascular tone, and natriuresis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.