Thermo Fisher Scientific KAT2B Polyclonal Antibody
KAT2B 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 응용 분야(WB, IHC, ICC, Flow, ELISA)에 적합하며, 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific KAT2B Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human KAT2B (amino acids 451–550) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It exhibits significant acetyltransferase activity toward core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Additionally, PCAF acts as a circadian transcriptional coactivator enhancing NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimer activity. It is involved in heart and limb development by mediating acetylation and nucleocytoplasmic shuttling of TBX5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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