ELK Biotechnology Na+ CP type VIIα rabbit pAb
Voltage-gated sodium channel protein type VIIα에 대한 rabbit polyclonal antibody로, WB 및 IHC 분석에 적합. 인간 SCN7A 유래 펩타이드로 면역화됨. 세포막에 위치하며, 신경 및 근육의 활동전위 연구에 활용 가능. 고순도 IgG 형태로 -20°C에서 1년 보관 가능.
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제품명
Na+ CP type VIIα rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SCN7A; SCN6A; Sodium channel protein type 7 subunit alpha; Putative voltage-gated sodium channel subunit alpha Nax; Sodium channel protein cardiac and skeletal muscle subunit alpha; Sodium channel protein type VII subunit alpha |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human SCN7A (AA range: 771–820) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 200 kD |
| GeneID (Human) | 6332 |
| Human Swiss-Prot No | Q01118 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Monkey |
Background
This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization.
This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positively charged residues than other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins.
Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown.
[provided by RefSeq, Dec 2011]
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