ELK Biotechnology p70 S6 kinase α (phospho Ser427) rabbit pAb
인간 p70 S6 kinase α (phospho Ser427)에 특이적인 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 사용 가능. mTOR 신호전달 관련 단백질 연구에 적합하며, 고순도 IgG(1 mg/ml)로 안정적 저장(-20°C, 1년) 가능.
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제품명
p70 S6 kinase α (phospho Ser427) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RPS6KB1; STK14A; Ribosomal protein S6 kinase beta-1; S6K-beta-1; S6K1; 70 kDa ribosomal protein S6 kinase 1; P70S6K1; p70-S6K 1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha; p70 S6 kinase |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human p70 S6 Kinase around the phosphorylation site of Ser427 (AA range: 393–442) |
| Host Species | Rabbit |
| Storage Conditions | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 70 kD |
| GeneID (Human) | 6198 |
| Human Swiss-Prot No. | P23443 |
| Cellular Localization | Cell junction, synapse, synaptosome, mitochondrion outer membrane, mitochondrion. Colocalizes with URI1 at mitochondrion. Isoform Alpha I: Nucleus, Cytoplasm. Isoform Alpha II: Cytoplasm. |
| Species Reactivity | Human; Mouse; Rat |
Background
Ribosomal protein S6 kinase B1 (RPS6KB1) is a member of the ribosomal S6 kinase family of serine/threonine kinases. This protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini, which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. (RefSeq, Jan 2013)
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