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ELK Biotechnology Rb (phospho Ser795) rabbit pAb
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ELK Biotechnology Rb (phospho Ser795) rabbit pAb

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Retinoblastoma 단백질의 Ser795 인산화 부위에 특이적인 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 적합하며 고감도 검출 가능. 세포주기 음성 조절 및 종양 억제 관련 연구에 활용. -20°C에서 1년 안정 저장.

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pk
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ELK Biotechnology ES6993-100UL Rb (phospho Ser795) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES6993-50UL Rb (phospho Ser795) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology Rb (phospho Ser795) rabbit pAb

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Rb (phospho Ser795) rabbit pAb

공급업체

ELK Biotechnology


제품 정보

항목 내용
Alternative Names RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Applications WB; IHC; IF; ELISA
Recommended Dilutions Western Blot: 1/500 - 1/2000
Immunohistochemistry: 1/100 - 1/300
ELISA: 1/10000
Not yet tested in other applications
Immunogen Synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser795 (AA range: 761–810)
Storage -20°C / 1 year
Host Rabbit
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 106 kD
GeneID (Human) 5925
Human Swiss-Prot No P06400
Cellular Localization Nucleus. During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization.
Species Reactivity Human; Mouse; Rat

Background

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. It stabilizes constitutive heterochromatin to maintain chromatin structure. The active, hypophosphorylated form binds transcription factor E2F1. Defects in this gene cause childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
[provided by RefSeq, Jul 2008]


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