ELK Biotechnology Raf-1 (phospho Ser43) rabbit pAb
Raf-1 (phospho Ser43) rabbit polyclonal antibody, suitable for WB, IF, ELISA, and IHC applications. Recognizes phosphorylated Ser43 site of human C-RAF. High specificity and sensitivity with broad species reactivity (Human, Mouse, Rat). Stored at -20°C...
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제품명
Raf-1 (phospho Ser43) rabbit pAb
공급업체
ELK Biotechnology
제품 설명
Raf-1 (phospho Ser43) rabbit polyclonal antibody는 인간 C-RAF 단백질의 Ser43 인산화 부위를 인식하도록 설계된 항체입니다. MAP kinase signaling pathway 연구에 적합하며, 다양한 응용 분야에서 높은 특이성과 재현성을 제공합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RAF1; RAF; RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF; cRaf; Raf-1 |
| Applications | WB; IF; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IF/ICC 1:50–200; ELISA 1:2000–20000; IHC-p 1:50–200 |
| Immunogen | Synthesized peptide derived from human C-RAF around the phosphorylation site of Ser43 (AA range: 11–60) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 73 kD |
| GeneID (Human) | 5894 |
| Human Swiss-Prot No. | P04049 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, Cell membrane, Mitochondrion, Nucleus. Colocalizes with RGS14 and BRAF in both cytoplasm and membranes. Phosphorylation at Ser-259 impairs membrane accumulation. Recruited to the cell membrane by active Ras protein. Phosphorylation at Ser-338 and Ser-339 by PAK1 is required for mitochondrial localization. Retinoic acid-induced Ser-621 phosphorylated form predominantly localized at the nucleus. |
Background
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), functioning downstream of Ras family GTPases. Activated RAF1 phosphorylates MEK1 and MEK2, which subsequently activate ERK1 and ERK2. These kinases regulate cell division, apoptosis, differentiation, and migration. Mutations in RAF1 are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
(RefSeq, Jul 2008)
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