ELK Biotechnology SH-PTP1 rabbit pAb
인간 SHP-1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 세포 내 신호 조절 연구에 적합하며, 사람·마우스·랫트 반응성. -20°C에서 1년 보관 가능.
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제품명
SH-PTP1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PTPN6; HCP; PTP1C; Tyrosine-protein phosphatase non-receptor type 6; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SHP-1 (AA range: 502-551) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 67 kD |
| Gene ID (Human) | 5777 |
| Human Swiss-Prot No. | P29350 |
| Cellular Localization | Cytoplasm, Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate various cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. The N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains and mediate the interaction with substrates. This PTP is expressed primarily in hematopoietic cells and functions as an important regulator of multiple signaling pathways in these cells. It interacts with and dephosphorylates a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants encoding distinct isoforms have been reported. (RefSeq, Jul)
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