ELK Biotechnology SH-PTP1 (phospho Tyr536) rabbit pAb
Human SHP-1 단백질의 Tyr536 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 적합. 세포 성장 및 신호전달 연구에 활용 가능. 고순도 IgG 형태로 -20°C에서 1년 보관 가능.
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제품명
SH-PTP1 (phospho Tyr536) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PTPN6; HCP; PTP1C; Tyrosine-protein phosphatase non-receptor type 6; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human SHP-1 around the phosphorylation site of Tyr536 (AA range: 502–551) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 67 kD |
| GeneID (Human) | 5777 |
| Human Swiss-Prot No. | P29350 |
| Cellular Localization | Cytoplasm and nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between cytoplasm and nucleus via association with PDPK1. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene belongs to the protein tyrosine phosphatase (PTP) family, known to regulate various cellular processes such as growth, differentiation, mitotic cycle, and oncogenic transformation. The N-terminal region contains two tandem Src homolog (SH2) domains that mediate interaction with phospho-tyrosine substrates. Expressed mainly in hematopoietic cells, SHP-1 acts as a key regulator of multiple signaling pathways and dephosphorylates various phospho-proteins involved in hematopoietic signaling. Multiple alternatively spliced variants encoding distinct isoforms have been reported.
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