ELK Biotechnology Brk (phospho Tyr447) rabbit pAb
Brk (phospho Tyr447) rabbit pAb는 인산화 Tyr447 부위를 인식하는 rabbit polyclonal 항체로, WB, IF, ELISA에 적합합니다. PTK6/BRK 단백질 검출에 활용되며, 세포 내 신호전달 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
Brk (phospho Tyr447) rabbit pAb
제품 개요
이 항체는 인간 Breast Tumor Kinase(PTK6)의 Tyr447 인산화 부위를 인식하도록 제작된 rabbit polyclonal antibody입니다. 세포 내 신호전달 및 암 관련 단백질 발현 연구에 활용할 수 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PTK6; BRK; Protein-tyrosine kinase 6; Breast tumor kinase; Tyrosine-protein kinase BRK |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunofluorescence: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Breast Tumor Kinase around the phosphorylation site of Tyr447 (AA range: 402–451) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kDa |
| Gene ID (Human) | 5753 |
| Human Swiss-Prot No. | Q13882 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Cytoplasm, Nucleus, Cell projection (ruffle), Membrane. Colocalizes with KHDRBS1, KHDRBS2, or KHDRBS3 within the nucleus. Shows nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate. |
Background
Protein tyrosine kinase 6 (PTK6, also known as BRK) is a cytoplasmic non-receptor protein kinase that functions as an intracellular signal transducer in epithelial tissues. Overexpression in mammary epithelial cells increases sensitivity to epidermal growth factor and induces a partially transformed phenotype. Expression has been detected at low levels in some breast tumors but not in normal breast tissue. The protein undergoes autophosphorylation, and alternative splicing results in multiple transcript variants (RefSeq, Jan 2012).
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