ELK Biotechnology PTEN (phospho Ser380) rabbit pAb
PTEN 단백질의 Ser380 인산화 부위를 인식하는 rabbit polyclonal antibody. IHC, IF, ELISA에 사용 가능하며, 암 억제 관련 연구에 적합. 고순도 IgG 형식으로 1 mg/ml 농도, -20°C에서 1년 보관 가능.
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PTEN (phospho Ser380) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PTEN; MMAC1; TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen | Synthesized peptide derived from human PTEN around the phosphorylation site of Ser380 (AA range: 366–395) |
| Species Reactivity | Human; Mouse; Rat |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kD |
| GeneID (Human) | 5729 |
| Human Swiss-Prot No | P60484 |
| Cellular Localization | Cytoplasm, Nucleus, PML body. Monoubiquitinated form is nuclear, nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982). Isoform alpha: Secreted; may reenter cells via poly-Arg motif. |
Background
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin-like domain as well as a catalytic domain similar to that of dual-specificity protein tyrosine phosphatases. Unlike most protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate and functions as a tumor suppressor by negatively regulating the AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, thought to be associated with the mitochondrial inner membrane and may help regulate energy metabolism.
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