ELK Biotechnology PTEN (phospho Ser385) rabbit pAb
Human PTEN (phospho Ser385) 단백질을 인식하는 rabbit polyclonal antibody로, IHC, IF, ELISA에 적합하며 암 관련 신호전달 연구에 유용. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 안정 저장 가능.
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PTEN (phospho Ser385) rabbit pAb
공급업체
ELK Biotechnology
제품 설명
본 항체는 인간 PTEN 단백질의 Ser385 인산화 부위를 인식하는 rabbit polyclonal antibody입니다. 암 억제 유전자 PTEN의 기능 및 신호전달 경로 연구에 활용됩니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | PTEN; MMAC1; TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PTEN around phosphorylation site of Ser385 (AA range: 370–400) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 5728 |
| Human Swiss-Prot No | P60484 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, Nucleus, PML body. Monoubiquitinated form is nuclear; nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620). XIAP/BIRC4 promotes nuclear localization (PubMed:19473982). Isoform α may be secreted via a classical signal peptide and reenter cells with a poly-Arg motif. |
Background
This gene was identified as a tumor suppressor mutated in many cancers. The encoded protein is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase with a tensin-like and catalytic domain similar to dual specificity protein tyrosine phosphatases. It preferentially dephosphorylates phosphoinositide substrates, negatively regulating intracellular phosphatidylinositol-3,4,5-trisphosphate levels and AKT/PKB signaling. A non-canonical upstream initiation site produces a longer isoform associated with the mitochondrial inner membrane, potentially involved in energy regulation.
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