ELK Biotechnology Patched rabbit pAb
Patched 단백질에 대한 rabbit polyclonal antibody로, WB·IHC·IF·ELISA에 사용 가능. 인간 및 생쥐 반응성. 세포막 다중 통과 단백질 인식. 종양 억제 유전자 PTCH1 연구에 적합.
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제품명
Patched rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PTCH1; PTCH; Protein patched homolog 1; PTC; PTC1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Patched (AA range: 1–50) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 160 kD |
| GeneID (Human) | 5727 |
| Human Swiss-Prot No | Q13635 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Mouse |
Background
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. (provided by RefSeq, Jul 2008)
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