ELK Biotechnology Bad (phospho Ser134) rabbit pAb
Bad 단백질의 Ser134 인산화 부위를 인식하는 rabbit polyclonal antibody로, 세포사멸 조절 연구에 적합합니다. WB, IHC, IF, ELISA 등 다양한 응용에 사용 가능하며, 고순도 IgG로 안정적 신호를 제공합니다.
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제품명
Bad (phospho Ser134) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | BAD; BBC6; BCL2L8; Bcl2 antagonist of cell death; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2-associated death promoter |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human BAD around the phosphorylation site of Ser134 (AA range: 100–149) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 28 kDa |
| Gene ID (Human) | 572 |
| Human Swiss-Prot No. | Q92934 |
| Cellular Localization | Mitochondrion outer membrane, Cytoplasm. Colocalizes with HIF3A in the cytoplasm. Upon phosphorylation, relocates to cytoplasm. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a member of the BCL-2 family, known as regulators of programmed cell death. This protein promotes apoptosis by forming heterodimers with BCL-xL and BCL-2, counteracting their anti-apoptotic effects. Its proapoptotic activity is regulated through phosphorylation. Protein kinases such as AKT and MAP kinase, as well as protein phosphatase calcineurin, are involved in its regulation. Alternative splicing results in two transcript variants encoding the same isoform.
(Information provided by RefSeq, Jul 2008)
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