ELK Biotechnology Saposin rabbit pAb

제품 설명

Saposin rabbit pAb는 인간 PSAP(Prosaposin) 유래 합성 펩타이드(AA 307–356)를 면역원으로 제작된 토끼 다클론 항체입니다. 이 항체는 리소좀 및 분비 단백질의 발현 분석에 유용하며, 다양한 응용 분야에서 사용 가능합니다.

제품 정보

Background

This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A–D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. (RefSeq, Feb 2016)