ELK Biotechnology PKR (phospho Thr258) rabbit pAb
PKR 단백질의 Thr258 인산화 부위를 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 사용 가능하며, 다양한 종(Human, Rat, Mouse)에 반응. 세포 내 PKR 활성 연구 및 신호전달 분석에 적합.
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제품명
PKR (phospho Thr258) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EIF2AK2; PKR; PRKR; Interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein kinase |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PKR around the phosphorylation site of Thr258. (AA range: 226-275) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 62 kDa |
| GeneID (Human) | 5610 |
| Human Swiss-Prot No | P19525 |
| Cellular Localization | Cytoplasm, Nucleus, Cytoplasm (perinuclear region). Nuclear localization is elevated in acute leukemia, myelodysplastic syndrome (MDS), melanoma, breast, colon, prostate, and lung cancer patient samples or cell lines, as well as neurocytes from advanced Creutzfeldt-Jakob disease patients. |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.
[provided by RefSeq, Oct 2011]
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