ELK Biotechnology ERK 2 rabbit pAb
ERK 2 rabbit pAb는 MAPK/ERK 신호전달 연구용 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간 p42 MAPK 유래 펩타이드로 제작된 polyclonal 항체이며, 세포 증식·분화 연구에 유용합니다. -20°C에서 장기 보관 가능합니다.
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제품명
ERK 2 rabbit pAb
제품 개요
ERK 2 rabbit pAb는 MAP kinase family 단백질을 인식하는 토끼 polyclonal 항체입니다. 다양한 생물학적 신호 전달 경로 연구에 사용되며, 세포 증식, 분화, 전사 조절 및 발달 과정 연구에 유용합니다.
주요 특징
- 인간 p42 MAPK 펩타이드(AA 136–185)로부터 제작
- WB, IHC, IF, ELISA 등 다양한 응용 가능
- Polyclonal IgG 항체
- Human, Mouse, Rat 반응성
스펙 정보
| 항목 | 내용 |
|---|---|
| Product name | ERK 2 rabbit pAb |
| Alternative Names | MAPK1; ERK2; PRKM1; PRKM2; Mitogen-activated protein kinase 1; MAP kinase 1; MAPK 1; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human p42 MAPK (AA range: 136–185) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kD |
| GeneID (Human) | 5594 |
| Human Swiss-Prot No | P28482 |
| Cellular Localization | Cytoplasm, cytoskeleton, spindle, nucleus, centrosome, membrane (caveola), focal adhesion. Associated with spindle during prometaphase and metaphase. PEA15-binding and phosphorylated DAPK1 promote cytoplasmic retention. Phosphorylation at Ser-246/248 and Thr-190 promotes nuclear localization. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the MAP kinase family. MAP kinases (ERKs) act as an integration point for multiple biochemical signals and are involved in cellular processes such as proliferation, differentiation, transcription regulation, and development. Activation requires phosphorylation by upstream kinases. Upon activation, the kinase translocates to the nucleus and phosphorylates nuclear targets. It may also act as a transcriptional repressor independent of its kinase activity. Two alternatively spliced transcript variants encoding the same protein have been reported.
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