ELK Biotechnology PKC θ (phospho Thr538) rabbit pAb
PKC θ (phospho Thr538) rabbit pAb는 인간, 마우스, 랫트에 반응하는 폴리클로날 항체로 T세포 활성화 연구에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며, Thr538 인산화 부위 특이적 인식. 세포질 및 세포막 위치 단백질 검출에 유용.
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제품명
PKC θ (phospho Thr538) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PRKCQ; PRKCT; Protein kinase C theta type; nPKC-theta |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PKC theta around the phosphorylation site of Thr538 (AA range: 504–553) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 81 kD |
| Gene ID (Human) | 5588 |
| Human Swiss-Prot No | Q04759 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm; Cell membrane; Peripheral membrane protein. In resting T-cells, mostly localized in cytoplasm. Upon TCR stimulation, associates with lipid rafts and localizes in the immunological synapse. |
Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases activated by calcium and diacylglycerol. PKC family members phosphorylate various protein targets and are involved in diverse cellular signaling pathways. They also act as receptors for phorbol esters, known tumor promoters. Each PKC isoform has a specific expression pattern and distinct biological role.
PKC θ is a calcium-independent, phospholipid-dependent protein kinase essential for T-cell activation. It mediates activation of transcription factors NF-κB and AP-1, linking T cell receptor (TCR) signaling to transcriptional activation.
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