ELK Biotechnology PKC θ (phospho Ser676) rabbit pAb
PKC θ (phospho Ser676) rabbit pAb는 인간, 마우스, 랫트 시료에 반응하는 폴리클로날 항체로, T세포 활성화 연구에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며, Ser676 인산화 부위를 인식합니다. 안정적인 IgG 항체로 -20°C에서 1년 보관 가능합니다.
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PKC θ (phospho Ser676) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | PKC θ (phospho Ser676) rabbit pAb |
| Alternative Names | PRKCQ; PRKCT; Protein kinase C theta type; nPKC-theta |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/5000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human PKC theta around phosphorylation site of Ser676 (AA range: 643–692) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 82 kDa |
| Gene ID (Human) | 5588 |
| Human Swiss-Prot No. | Q04759 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm; Cell membrane; Peripheral membrane protein. In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and localizes in the immunological synapse. |
Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases activated by calcium and diacylglycerol. PKC family members phosphorylate a wide range of protein targets and are involved in diverse cellular signaling pathways. They also act as major receptors for phorbol esters, a class of tumor promoters. Each PKC isoform has a distinct expression profile and role. PKC θ is a calcium-independent, phospholipid-dependent kinase crucial for T-cell activation, required for activation of NF-κB and AP-1 transcription factors, and may link TCR signaling to transcriptional activation. (RefSeq, Jul 2008)
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