ELK Biotechnology Girdin (phospho Ser1417) rabbit pAb
Girdin 단백질의 Ser1417 인산화 부위를 인식하는 토끼 폴리클로날 항체입니다. IHC, IF, ELISA에 사용 가능하며 세포 이동 및 세포골격 재구성 연구에 적합합니다. Human 및 Mouse 시료에 반응하며 -20°C에서 1년 보관 가능합니다.
- 카탈로그번호
- ES6748-xxxxx (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Girdin (phospho Ser1417) rabbit pAb
제품명
Girdin (phospho Ser1417) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CCDC88A; APE; GRDN; KIAA1212; Girdin; Akt phosphorylation enhancer; Coiled-coil domain-containing protein 88A; G alpha-interacting vesicle-associated protein; GIV; Girders of actin filament; Hook-related protein 1; HkRP1 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100–1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Girdin around the phosphorylation site of Ser1417 (AA range: 1383–1432) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 55704 |
| Human Swiss-Prot No. | Q3V6T2 |
| Species Reactivity | Human; Mouse |
세포 내 위치 (Cellular Localization)
Cell membrane; Peripheral membrane protein; Cytoplasm (cytosol); Cytoplasmic vesicle; Cell projection (lamellipodium); Cytoplasm (cytoskeleton, cilium basal body); Cytoplasm (cytoskeleton, microtubule organizing center, centrosome, centriole).
Localizes to the cytosol in unstimulated cells, while EGF stimulation promotes membrane localization and guanine nucleotide exchange factor activity (PubMed:27864364).
Localizes to the cell membrane through interaction with phosphoinositides (PubMed:16139227, PubMed:15882442).
Background
This gene encodes a member of the Girdin family of coiled-coil domain-containing proteins. The encoded protein is an actin-binding protein activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. It enhances Akt signaling by mediating PI3K-dependent activation of Akt via growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression and phosphorylation of this protein may contribute to cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (RefSeq, Dec 2011)
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.