ELK Biotechnology CD158f2 rabbit pAb
CD158f2 rabbit pAb는 사람, 쥐, 생쥐에서 반응하는 다클론 항체로, KIR2DL5B 단백질을 인식합니다. WB, IF, ELISA에 사용 가능하며, 세포막 단백질 검출에 적합합니다. -20°C에서 1년 보관 가능하며 농도는 1 mg/ml입니다.
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제품명
CD158f2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | KIR2DL5B; CD158F; CD158F2; KIR2DL5; KIR2DLX; Killer cell immunoglobulin-like receptor 2DL5B; CD158 antigen-like family member F2; Killer cell immunoglobulin-like receptor 2DLX; CD antigen CD158f2 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human KIR2DL5B. AA range: 161–210 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 40 kD |
| Gene ID (Human) | 553128 |
| Human Swiss-Prot No | Q8NHK3 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
Killer cell immunoglobulin-like receptor, two Ig domains and long cytoplasmic tail 5B (KIR2DL5B) is a transmembrane glycoprotein expressed by natural killer (NK) cells and subsets of T cells. KIR genes are polymorphic and highly homologous, located in a cluster on chromosome 19q13.4 within the leukocyte receptor complex (LRC). The gene content of the KIR cluster varies among haplotypes, although several framework genes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) are found in all haplotypes.
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by the length of the cytoplasmic domain (L or S). Proteins with long cytoplasmic domains transmit inhibitory signals via immune tyrosine-based inhibitory motifs (ITIM), whereas those with short cytoplasmic domains lack this motif.
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