ELK Biotechnology PLC γ2 (phospho Tyr1217) rabbit pAb
PLCγ2 단백질의 Tyr1217 인산화 부위를 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 세포 신호전달 연구 및 인산화 단백질 분석에 적합.
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제품명
PLC γ2 (phospho Tyr1217) rabbit pAb
제품 개요
PLCγ2 단백질의 Tyr1217 인산화 부위를 인식하는 토끼 폴리클로날 항체입니다. 세포 내 신호전달 경로 연구 및 인산화 단백질 분석에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PLCG2 around the phosphorylation site of Tyr1217 (AA range: 1186–1235) |
| Host Species | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 148 kDa |
| Gene ID (Human) | 5336 |
| Human Swiss-Prot No. | P16885 |
| Cellular Localization | Intracellular, cytosol, plasma membrane, extracellular exosome |
| Species Reactivity | Human, Mouse, Rat |
Background
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. (RefSeq, Mar 2014)
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