ELK Biotechnology tPA rabbit pAb
인간 tPA를 인식하는 rabbit polyclonal antibody로, Western blot과 ELISA에 적합합니다. 고순도 IgG 형태로 제공되며, 세포 외 분비 단백질 검출에 활용됩니다. -20°C에서 1년 보관 가능하며, 인간·마우스·랫트 반응성을 가집니다.
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ELK Biotechnology tPA rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | tPA rabbit pAb |
| Alternative Names | PLAT; Tissue-type plasminogen activator; t-PA; t-plasminogen activator; tPA; Alteplase; Reteplase |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human tPA (AA range: 38–87) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 63 kD |
| GeneID (Human) | 5327 |
| Human Swiss-Prot No | P00750 |
| Cellular Localization | Secreted, extracellular space |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains, which associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, leading to excessive bleeding, while decreased activity results in hypofibrinolysis, which can cause thrombosis or embolism. Alternative splicing of this gene produces multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. (RefSeq, Jan 2016)
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