ELK Biotechnology cPLA2 (phospho Ser505) rabbit pAb
Human, Mouse, Rat에 반응하는 cPLA2 (phospho Ser505) rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 사용 가능. Ser505 인산화 부위 기반 합성 펩타이드로 제작. 세포 내 칼슘 의존적 막 이동 특성. 고품질 IgG, 1 mg/ml 농도.
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제품명
cPLA2 (phospho Ser505) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PLA2G4A; CPLA2; PLA2G4; Cytosolic phospholipase A2; cPLA2; Phospholipase A2 group IVA |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human c-PLA2 around the phosphorylation site of Ser505 (AA range: 471–520) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 110 kD |
| GeneID (Human) | 5321 |
| Human Swiss-Prot No | P47712 |
| Cellular Localization | Cytoplasm, Golgi apparatus membrane, nuclear envelope. Translocates to intracellular membranes in a calcium-dependent way. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes hydrolysis of membrane phospholipids to release arachidonic acid, which is metabolized into eicosanoids such as prostaglandins and leukotrienes. These lipid-based hormones regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis also produces lysophospholipids that form platelet-activating factor. The enzyme is activated by increased intracellular Ca²⁺ levels and phosphorylation, causing translocation from cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. (RefSeq, Jul 2015)
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