ELK Biotechnology Pim-1 (phospho Tyr309) rabbit pAb
Pim-1 (phospho Tyr309) 인산화 부위를 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며 세포 증식 및 생존 관련 신호전달 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
Pim-1 (phospho Tyr309) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PIM1; Serine/threonine-protein kinase pim-1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Pim-1 around the phosphorylation site of Tyr309. AA range: 281-330 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 45 kD |
| Gene ID (Human) | 5292 |
| Human Swiss-Prot No | P11309 |
| Cellular Localization | [Isoform 1]: Cytoplasm, Nucleus [Isoform 2]: Cell membrane |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810). [provided by RefSeq, Aug 2011]
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