ELK Biotechnology P-glycoprotein 1 rabbit pAb
P-glycoprotein 1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫드에 반응하며, 다약제 내성 관련 연구에 적합. 합성 펩타이드(AA 534-583)를 면역원으로 제작됨. -20°C에서 1년 보관 가능.
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P-glycoprotein 1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | P-glycoprotein 1 rabbit pAb |
| Alternative Names | p-pg; ABCB1; MDR1; PGY1; Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD antigen CD243 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | IHC: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human P-glycoprotein 1 (AA range: 534–583) |
| Storage | -20°C, 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 5243 |
| Human Swiss-Prot No. | P08183 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein; Apical cell membrane |
| Species Reactivity | Human; Mouse; Rat |
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein belongs to the MDR/TAP subfamily, involved in multidrug resistance. It acts as an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity, responsible for decreased drug accumulation in multidrug-resistant cells and often mediating resistance to anticancer drugs. Additionally, it functions as a transporter in the blood-brain barrier.
[Provided by RefSeq, Jul 2008]
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