Thermo Fisher Scientific GluR6 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
ITFNKTNGLR TDFDLDVISL KEEGLEKIGT WDPASGLNMT ESQKGKPANI TDSLSNRSLI VTTILEEPYV LFKKSDKPLY GNDRFEGYCI DLL

Target Information

Glutamate receptors are the primary excitatory neurotransmitter receptors in the mammalian brain and are activated during various normal neurophysiological processes.
The kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels, includes this gene product.
The subunit encoded by this gene is edited at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex.
Different isoforms of this gene have been described due to alternatively spliced transcript variants.
Mutations in this gene have been linked to autosomal recessive cognitive disability.
GRIK2-associated diseases include Neurodevelopmental Disorder with Impaired Language and Ataxia, and with or without Seizures and Intellectual Developmental Disorder, Autosomal Recessive 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.