Thermo Fisher Scientific Phospho-SMAD1 (Ser206) Polyclonal Antibody
SMAD1 단백질의 인산화된 Ser206 부위를 인식하는 Rabbit Polyclonal 항체. Western blot과 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제된 액상 항체로, 보존제 없이 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunoprecipitation (IP) | 1:25 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer206 of Smad1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982225 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The protein encoded by this gene belongs to the SMAD family, which are signal transducers and transcriptional modulators mediating multiple signaling pathways. SMAD1 mediates signals of bone morphogenetic proteins (BMPs), involved in cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand binding, SMAD1 is phosphorylated and activated by BMP receptor kinase, forming a complex with SMAD4 for transcriptional regulation. It is targeted by SMURF1 and SMURF2 E3 ubiquitin ligases for ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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