Thermo Fisher Scientific NOTCH3 Monoclonal Antibody (3E2D9)
인간 NOTCH3 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 ELISA에 적합합니다. 정제된 재조합 단백질(AA 47-156)을 면역원으로 사용하였으며, Protein G로 정제된 1 mg/mL 액상 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E2D9 |
| Immunogen | Purified recombinant fragment of human Notch3 (AA: 47–156) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090804 |
Target Information
NOTCH3 is the third discovered human homologue of the Drosophila melanogaster type I membrane protein Notch. In Drosophila, Notch interaction with its cell-bound ligands (Delta, Serrate) establishes an intercellular signaling pathway that plays a key role in neural development. Homologues of these ligands have also been identified in humans.
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination.
Mutations in NOTCH3 are known to cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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