Thermo Fisher Scientific Ion AmpliSeq Polyploidy Panel Kit with Ion 530 Chips (480 Samples)

Ion AmpliSeq™ Polyploidy Panel Kit with Ion 530™ Chips (480 Samples)

The Ion GeneStudio System–compatible Ion AmpliSeq Polyploidy Panel Kit empowers accurate quality controls in preimplantation genetic testing for aneuploidy (PGT-A) by leveraging SNP-based assessments.

Key Benefits

• Germline SNP detection from embryo biopsy samples — No parental DNA required, enabling direct extraction of genetic insights from the sample.
• Comprehensive genetic coverage — Includes 74 microhaplotype amplicons for human identification and 368 single SNP amplicons representing the population at large. Covers a total of 590 SNP sites for enhanced PGT-A analysis.
• Triploidy 69,XXX identification — Utilizes tri-allelic microhaplotype sites and allele frequency distributions to confidently identify triploidy 69,XXX, which can resemble normal 46,XX on conventional PGT-A plots.
• Mitigation of maternal contamination risk — Reliable assessment of cumulus cell DNA contamination through tri-allelic microhaplotype sites, helping prioritize low-risk samples.
• Sibling embryo tracking — SNP clustering enables identification of genetically related embryos, preventing sample mix-ups.

Application

Enhance embryo prioritization in PGT-A through SNP-based quality controls.
Single nucleotide polymorphisms (SNPs) provide unique genetic variations that aid in triploidy detection, maternal contamination assessment, and embryo selection for IVF research.

Notes

• Compatible with Ion GeneStudio System

Specifications

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