Thermo Fisher Scientific STAT1 Monoclonal Antibody (15H3)
STAT1 단백질을 인식하는 Mouse Monoclonal Antibody (Clone 15H3). Western blot, ICC/IF, IP에 적합. Human 및 비인간 영장류 반응성. Protein A 정제, 1 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution / Amount | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 3 publications |
| Immunocytochemistry (ICC/IF) | 1:20 | - |
| Immunoprecipitation (IP) | 2 µg | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 15H3 |
| Immunogen | Protein expressed in 293T cell transfected with human STAT1 expression vector. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 30% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154072 |
Product Specific Information
- This antibody requires overnight incubation in Western blot for optimal performance.
- Do not use this antibody in a Fast Western blotting procedure.
Target Information
STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. It can be activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6. STAT1 regulates genes involved in cell growth, apoptosis, immune responses, and lipid metabolism. It plays a key role in mediating cell viability in response to various stimuli and pathogens.
The STAT1 gene is located on chromosome 2 and is activated through phosphorylation by JAK tyrosine kinases, leading to nuclear translocation and transcriptional regulation. Among the seven STAT types, STAT1, STAT3, STAT5a, and STAT5b have broad activation profiles. STAT1 is activated by ligands including the IFN family (IFN-α, IFN-β, IFN-γ, IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, G-CSF), and receptor tyrosine kinases (EGF, PDGF, CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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