Thermo Fisher Scientific STAT1 Monoclonal Antibody (15H3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• This antibody requires overnight incubation in Western blot for optimal performance.
• Do not use this antibody in a Fast Western blotting procedure.

Target Information

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. It can be activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6. STAT1 regulates genes involved in cell growth, apoptosis, immune responses, and lipid metabolism. It plays a key role in mediating cell viability in response to various stimuli and pathogens.

The STAT1 gene is located on chromosome 2 and is activated through phosphorylation by JAK tyrosine kinases, leading to nuclear translocation and transcriptional regulation. Among the seven STAT types, STAT1, STAT3, STAT5a, and STAT5b have broad activation profiles. STAT1 is activated by ligands including the IFN family (IFN-α, IFN-β, IFN-γ, IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, G-CSF), and receptor tyrosine kinases (EGF, PDGF, CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.