Thermo Fisher Scientific IRG1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 177-266. Recombinant protein control fragment (Product #RP-109751). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IRG1,uniProtId:A6NK06-1,ncbiNodeId:9606,antigenRange:177-266,antigenLength:481,antigenImageFileName:PA5-144875_IRG1_A6NK06-1_Rabbit.svg,antigenImageFileNamePDP:PA5-144875_IRG1_A6NK06-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3091973

Product Specific Information

Immunogen sequence: LGLSSTKCRE ALAIAVSHAG APMANAATQT KPLHIGNAAK HGIEAAFLAM LGLQGNKQVL DLEAGFGAFY ANYSPKVLPS IASYSWLLDQ

Antigen sequence identity: Mouse 86%; Rat 87%

Target Information

Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; IRG1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.