Thermo Fisher Scientific Phospho-PAK4/5 (Ser99) Polyclonal Antibody
PAK4/5 인산화(Ser99) 부위를 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성 보유. 고순도 Protein A 정제 및 안정적 액상 형태로 연구용에 최적화.
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Thermo Fisher Scientific Phospho-PAK4/5 (Ser99) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human PAK4 around the phosphorylation site of Ser99 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
p21-activated kinases (PAKs) are serine/threonine kinases involved in controlling various cellular processes such as cell cycle regulation, cytoskeleton dynamics, apoptosis, oncogenic transformation, and transcription. They contain a p21-binding domain and are regulated by small GTP-binding proteins Rac and Cdc42, and lipids that stimulate autophosphorylation and substrate phosphorylation.
PAK4 is activated by phosphorylation at Ser-474 and is implicated in oncogenesis, being overexpressed in multiple human tumor cell lines. It plays roles in cytoskeleton regulation, cell migration, proliferation, and survival by phosphorylating targets including RAF1, BAD, and CTNND1. PAK4 stabilizes microtubules via MARK2 inhibition and modulates actin networks, influencing cell morphology and adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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