Thermo Fisher Scientific STEP Polyclonal Antibody
STEP 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 및 Mouse 시료에 반응합니다. Western blot, IHC, ELISA에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 장기 보관 시 -20°C에서 보관 권장.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1.0–2.0 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | PTPN5 antibody for an 18 amino acid peptide near the amino terminus of human PTPN5. The immunogen is within amino acids 180–230 of PTPN5. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718686 |
Target Information
Reversible phosphorylation of tyrosine residues is a key regulatory mechanism for numerous cellular events such as proliferation, differentiation, gene expression, and migration. Abnormalities in tyrosine phosphorylation contribute to various human diseases, including cancer and immune deficiencies.
There are at least 107 genes coding for protein tyrosine phosphatases (PTPs) in the human genome. All known PTPs possess a conserved 12 amino acid catalytic domain and differ by additional structural motifs.
Receptor-like PTPs have extracellular domains, a transmembrane region, and one or two intracellular phosphatase domains. Nonreceptor cytoplasmic PTPs contain a single phosphatase domain and additional motifs homologous to other protein classes.
PTPN5 (STEP), PTPRR, and PTPN7 form a family of phosphatases that specifically inactivate MAPKs (mitogen-activated protein kinases). Multiple STEP isoforms are found in the adult rat brain and are differentially enriched in regions associated with cognitive, affective, and motor behavior. Some isoforms arise through alternative splicing of the STEP gene, each with unique intracellular targets and functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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