Thermo Fisher Scientific TNFAIP8 Polyclonal Antibody
Human TNFAIP8 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며, 고순도의 항원 친화 크로마토그래피로 정제됨. PBS 및 글리세롤 기반 완충액에 보관, 연구용 전용.
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- PA563397
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TNFAIP8. Recombinant protein control fragment (Product #RP-101818). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648781 |
Product Specific Information
Immunogen sequence:
AKSHGRVNNV FDHFSDCEFL AALYNPFGNF KPHLQKLCDG INKMLDEENI
Highest antigen sequence identity to orthologs:
- Mouse: 96%
- Rat: 96%
Target Information
TNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8)
Also known as NFkappa B-inducible DED-containing protein (NDED), SCC-S2, or TNF-induced protein GG2-1.
This 198-amino-acid cytoplasmic protein is induced by NFkappa B and TNF. Its induction by TNF depends on NFkappa B activation. TNFalpha-IP 8 negatively mediates apoptosis and may play a role in tumor progression by specifically inhibiting caspase-8 activity, thereby preventing BID cleavage and caspase-3 activation during TNF-mediated apoptosis.
Expression:
High levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta, and various tumor tissues, as well as fetal lung, liver, and kidney.
Present as three isoforms produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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