Thermo Fisher Scientific SESN1 Polyclonal Antibody
SESN1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. Western blot 및 IHC(P)에서 사용 가능하며, 인간과 랫트 시료에 반응합니다. p53 관련 세포 스트레스 반응 연구에 유용합니다. 항원 친화 크로마토그래피로 정제된 액상 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human SESN1 (aa 271–320) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635585 |
Product Specific Information
This antibody detects endogenous levels of total SESN1 protein.
Target Information
The SESN1 gene encodes a member of the sestrin family, which is induced by the p53 tumor suppressor protein and plays a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase (AMPK), leading to inhibition of the mammalian target of rapamycin (mTOR). It also contributes to antioxidant defense by regenerating overoxidized peroxiredoxins. Expression of this gene may serve as a marker for radiation exposure. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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