Thermo Fisher Scientific HIP2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: A549, HeLa, HepG2, HCT116, mouse brain
• Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (98%), Pig (100%), Chicken (99%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

HIP2 accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
In vitro, it catalyzes the synthesis of Lys-48-linked polyubiquitin chains, mediates selective degradation of short-lived and abnormal proteins, and ubiquitinates huntingtin.
It may mediate foam cell formation by suppressing apoptosis of lipid-bearing macrophages through ubiquitination and degradation of p53/TP53.
HIP2 is proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B and may support ubiquitination of NFKB1.
During viral infections, it may participate in degradation of MHC class I heavy chains and RB1 depending on viral proteins.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.