Thermo Fisher Scientific IFN alpha Monoclonal Antibody (MMHA-2)
인간 IFN alpha에 특이적으로 결합하는 단클론 항체로 높은 친화도(Ka=10^9 M^-1)를 보유. 중화능 확인된 WB, IHC, Flow, ELISA 등 다양한 응용 가능. 순도 95% 이상, 엔도톡신 <1 EU/µg. -20°C 이하 보관, 연구용 전용 시약.
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Thermo Fisher Scientific IFN alpha Monoclonal Antibody (MMHA-2)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Flow Cytometry (Flow) | - | View 1 publication |
| ELISA (ELISA) | Assay-dependent | - |
| Neutralization (Neu) | Assay-dependent | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MMHA-2 |
| Immunogen | Human leukocyte interferon |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5 mg/mL |
| Purification | Ion-exchange chromatography, Size-exclusion chromatography |
| Storage Buffer | 165 mM sodium phosphate / 18 mM sodium citrate, pH 7.0 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| RRID | AB_223646 |
Product Specific Information
- Specificity: Neutralizes human interferon alpha; binds to human IFN alpha with high affinity (Ka = 10^9 M^-1).
- Activity: Interferon titrated using cytopathic effect inhibition assay. One neutralization unit = amount of serum required to neutralize one unit of human IFN alpha to an endpoint of 50%.
- Purity: >95%
- Endotoxin Level: <1 EU/µg
- Storage:
- Short-term: -20°C (less than 6 months)
- Long-term: aliquot and store at -70°C or below for full activity retention
- Refreezing: on dry ice or in dry ice/alcohol bath
- Dilution: use buffers containing protein (e.g., 0.1% BSA)
- Packaged by: PBL Assay Science
Target Information
IFN alpha (Interferon alpha) is a Type I interferon family member found exclusively in vertebrates. It interacts with its receptor to activate signaling pathways involved in innate immune defense against viral infections.
In humans, the IFN alpha gene is located on chromosome 9 and includes 14 alpha isoforms, along with beta, omega, epsilon, and kappa types. Homologous molecules exist in mammals, birds, reptiles, and fish.
Produced mainly by plasmacytoid dendritic cells, IFN alpha plays a key role in antiviral defense and modulation of adaptive immunity. Dysfunction is associated with diseases such as Hepatitis C and Hepatitis.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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