Thermo Fisher Scientific Aquaporin 2 Polyclonal Antibody, Atto 550

Thermo Fisher Scientific Aquaporin 2 Polyclonal Antibody, Atto 550

Applications

• Immunohistochemistry (Paraffin) [IHC(P)]: Tested dilution 1:50

Product Specifications

Product Specific Information

• Reconstitution: Add 50 µL double distilled water (DDW), depending on sample size.
• Ships as lyophilized powder at room temperature. Upon arrival, store at -20°C.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For longer storage, aliquot and store at -20°C. Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans. A vasopressin-induced cAMP increase results in phosphorylation of AQP2 at serine-256 and its translocation from intracellular vesicles to the apical membrane of principal cells. Serine-261 has been identified as a novel phosphorylation site; levels of phosphorylated S261 decrease with vasopressin treatment, suggesting its involvement in vasopressin-dependent AQP2 trafficking.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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