Thermo Fisher Scientific NEK8 Polyclonal Antibody
Human NEK8 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 버퍼에 40% 글리세롤 포함. 세포 주기 및 신장 발달 연구에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NEK8. Recombinant protein control fragment (Product # RP-98305) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644609 |
Product Specific Information
Immunogen sequence:
LSTERELFAW GRGDSGRLGL GTRESHSCPQ QVPMPPGQEA QRVVCGIDSS MILTVPGQAL ACGSNRFNKL G
Sequence identity:
- Mouse: 87%
- Rat: 86%
Target Information
NEK8 (NIMA-related kinase 8) is a serine/threonine kinase related to the NIMA gene of Aspergillus nodulins. It may play a role in cell cycle progression from G2 to M phase and is part of a complex of ciliary proteins required for renal and cardiovascular development. NEK8 interacts with polycystin signal transduction pathways and may regulate ciliary protein targeting and cytoskeletal structure in kidney tubule epithelial cells. It is also implicated in ciliary biogenesis.
Defects in NEK8 are associated with nephronophthisis type 9 (NPHP9) [MIM:613824], an autosomal recessive disorder leading to end-stage renal disease characterized by tubular modifications, basement membrane thickening, interstitial fibrosis, and medullary cysts.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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