Thermo Fisher Scientific Glucocorticoid Receptor Monoclonal Antibody (8E9)
Glucocorticoid Receptor (NR3C1)를 인식하는 Mouse IgG1 단클론 항체로, WB, ICC/IF, ELISA에 적합합니다. 26개 아미노산 펩타이드(150–176) 면역원 사용. 단백질 G 정제, PBS/BSA buffer, 1 mg/mL 농도. 연구용으로만 사용.
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Thermo Fisher Scientific Glucocorticoid Receptor Monoclonal Antibody (8E9)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| ELISA | 1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8E9 |
| Immunogen | 26 amino acid peptide corresponding to residues 150–176 of human GCR linked to thyroglobulin (human) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_794360 |
Product Specific Information
This antibody is not suitable for IHC applications.
Predicted molecular weight: 93.24 kDa
Target Information
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that functions as both a transcription factor and a regulator of other transcription factors.
It is typically found in the cytoplasm until ligand binding induces nuclear transport.
The receptor is expressed in various heart tissues including atria, ventricles, aorta, and septum.
Alternate splicing and promoter usage result in multiple transcript variants and isoforms.
Mutations in the NR3C1 gene can lead to glucocorticoid resistance.
GR interacts with chaperone proteins for ligand activation and binds steroids such as dexamethasone with nanomolar affinity.
Usage
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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