Thermo Fisher Scientific ATP8A2 Polyclonal Antibody
ATP8A2 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간 시료에 반응합니다. IHC(P)에서 1:500~1:1,000 희석으로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 신경세포 내 인지질 수송 및 시각·청각 기능 연구에 적합합니다.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ATP8A2. Recombinant protein control fragment (Product #RP-97955) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2638378 |
Product Specific Information
Immunogen sequence:
MLNGAGLDKA LKMSLPRRSR IRSSVGPVRS SLGYKKAEDE MSRATSVGDQ LEAPARTIYL NQPHLNKFRD NQISTAKYSV LTF
- Highest antigen sequence identity to the following orthologs:
- Mouse: 76%
- Rat: 66%
Target Information
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids.
Phospholipid translocation is implicated in vesicle formation and lipid signaling molecule uptake.
The ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE).
It functions in maintaining phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes, may be involved in vesicle trafficking in neuronal cells, and regulates neurite outgrowth in synergy with TMEM30A.
Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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