Thermo Fisher Scientific KMT2D Polyclonal Antibody
KMT2D 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. Human 시료에 반응하며, Affinity chromatography로 정제됨. PBS와 50% glycerol buffer에 보관하며, -20°C에서 저장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KMT2D (Accession O14686), corresponding to amino acid residues G1967–T2017 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900214 |
Product Specific Information
Antibody detects endogenous levels of total MLL2.
Target Information
KMT2D is a histone methyltransferase that methylates Lys-4 of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation.
KMT2D acts as a coactivator for estrogen receptors by being recruited by ESR1 and activating transcription.
It is involved in chromatin organization, chromatin silencing, oocyte growth, oogenesis, and positive regulation of cell proliferation.
Mutations in the KMT2D gene cause Kabuki syndrome (KABUK1), which results in congenital mental retardation syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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