Thermo Fisher Scientific APRIL Polyclonal Antibody
APRIL 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot 및 ELISA에 적합하며, 인간 시료에 반응. Affinity Chromatography로 정제된 액상 제품으로, PBS/glycerol buffer에 보관. 면역 반응 및 세포 사멸 연구용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 105–247 of human TNFSF13 (NP_7420851) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.51 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804959 |
Product Specific Information
Immunogen sequence:
AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGL
Positive Samples: HeLa, HT-29, HepG2
Target Information
Members in the TNF superfamily regulate immune responses and induce apoptosis.
A novel member in the TNF family was recently identified and designated APRIL (A Proliferation-Inducing Ligand), TALL2 (TNF and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (TNF related death ligand 1a) in human and mouse.
Two receptors for APRIL were identified as TACI and BCMA.
APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death.
APRIL and its close relative BlyS, along with receptors BCMA and TACI, are involved in autoimmune diseases and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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