Thermo Fisher Scientific Contactin 2 Polyclonal Antibody
Rabbit polyclonal antibody targeting Contactin-2 (TAG1) for detection in human, mouse, and rat samples. Validated for Western blot and IHC (paraffin). Lyophilized form for long-term stability. For research use only.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of mature mouse Contactin-2 (TAG1) conjugated to an immunogenic carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Contactin-2.
Target Information
Contactin 2 (CNTN2, also known as transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system.
It is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol (GPI) anchor, six immunoglobulin (Ig)-like, and four Fibronectin type III (FNIII)-like domains.
Contactin 2 is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts to guide commissural axons without promoting their growth.
It binds with NgCAM in the same membrane (cis-binding). The heterophilic binding sites (Contactin 2/NgCAM and Contactin 2/NrCAM) are localized to the first four Ig domains, while the homophilic binding site (Contactin 2/Contactin 2) is localized to the FNIII domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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