Thermo Fisher Scientific ALKBH2 Polyclonal Antibody
인간 ALKBH2 단백질에 특이적인 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. 면역세포화학(ICC/IF)에 적합하며 항원 친화 크로마토그래피로 정제됨. 0.2 mg/mL 액상 형태, 4°C 보관 권장. 암 관련 연구 및 DNA 손상 복구 메커니즘 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ALKBH2. Recombinant protein control fragment (Product # RP-106087) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663677 |
Product Specific Information
Immunogen sequence:
DDERELAPGSP IASVSFGACR DFVFRHKDSR GKSPSRRVAV VRLPLAHGSL LMMNHPTNTH WYHSLPVRKK VLAPRVNLTF RK
Highest antigen sequence identity to the following orthologs:
- Mouse: 89%
- Rat: 88%
Target Information
The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repairing specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that, if left unchecked, could lead to cancerous cells.
Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors, indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme inhibited by nickel ions, suggesting that inhibition of ALKBH2 by nickel may contribute to cancer development.
Conversely, ALKBH2 mRNA and protein levels are increased in glioma cells following Photofrin-mediated photodynamic therapy, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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